High levels of cleaved caspase-3 in colorectal tumour stroma predict good survival
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چکیده
منابع مشابه
Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma
Apoptosis plays a dual role in cancer development and malignancy. The role of apoptosis-related caspases in cancer remains controversial, particularly in oral tongue squamous cell carcinoma (OTSCC). In this study, we examined the protein levels of cleaved caspase-3, caspase-3, caspase-8, and caspase-9 on tissue microarrays consisting of samples from 246 OTSCC patients by immunohistochemistry. W...
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A high incidence of colorectal cancer (CRC) has been established in the elderly population. Apoptosis is a key event in maintaining colon homeostasis, both in aging as well as in cancer prevention. Here, we report that colon morphology is affected during the aging process: crypt loss (P=0.045) and increasing distances between crypts (P=0.0001678) were observed, associated with a tendency for mu...
متن کاملThe relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer.
BACKGROUND Tumour stroma percentage (TSP) has previously been reported to predict survival in patients with colorectal cancer (CRC); however, whether this is independent of other aspects of the tumour microenvironment is unknown. In the present study, the relationship between TSP, the tumour microenvironment and survival was examined in patients undergoing elective, curative CRC resection. PA...
متن کاملDiVerential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma
Aim—To investigate an extent of smooth muscle diVerentiation of pericryptal fibroblasts. Methods—Expression of high molecular weight caldesmon (h-CD) and á smooth muscle actin was investigated in 123 invasive colorectal adenocarcinomas and their surrounding non-neoplastic tissues. Results—The monoclonal antibody to h-CD, which showed predominantly positive immunostaining in well diVerentiated s...
متن کاملDifferential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.
AIM To investigate an extent of smooth muscle differentiation of pericryptal fibroblasts. METHODS Expression of high molecular weight caldesmon (h-CD) and alpha smooth muscle actin was investigated in 123 invasive colorectal adenocarcinomas and their surrounding non-neoplastic tissues. RESULTS The monoclonal antibody to h-CD, which showed predominantly positive immunostaining in well differ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2013
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2013.166